Hej
Här kommer lite intressant läsning, jag har själv endo och har fått bort
mycket av värken med hjälp av trental.
Läkemedlet finns att få tag på om man ber en gynokolog tex att skriva en
dispans för att få beställa detta till ett apotek i Sverige.
http://www.treatendo.com/trental.htm 

Use of Trental for the Treatment of Endometriosis Chronic Pelvic Pain
 

 


 Activated inflammatory cells are a key feature of pelvic pain with endo.
The large quantities of inflammatory hormones produced in the pelvis by
macrophages and other immune cells cause a constant state of irritation.
Prostaglandins directly stimulate nerve endings to cause pain. Cytokines
such as tumor necrosis factor and interleukin-1 recruit more inflammatory
cells, causing a vicious circle of immune activation and pain. 

Nonsteroidal anti-inflammatory drugs (NSAIA) such as ibuprofin (Motrin)
and celecoxib (celebrex) are widely used in an effort to diminish
inflammation and reduce pain. Unfortunately, the effectiveness of this
class of drugs (as anyone who suffers from severe pelvic pain will attest)
is limited at best. This is because the motrin class of medications has a
very limited spectrum of action and does not adequately suppress the
activity of many immune cells that contribute to inflammation and pain in
endometriosis.

Pentoxifylline (Trental) is a unique medication that normalizes the
function of activated inflammatory cells. Trental is commonly used in the
treatment of circulatory disorders and immune diseases in which it is
important to normalize immune function. The inflammatory activity of most
immune cells, including macrophages, neutrophils, T-cells, and NK cells is
reduced by Trental. Importantly, while this medication normalizes immune
cell function and serves as an anti-inflammatory agent, it does not
suppress the immune system. Hence, women that take Trental are not at
increased risk of infection or other immunological disorders. 

These same immunomodulatory properties that make Trental an obvious
candidate for use in infertility treatment where activated NK cells
contribute to endometriosis-associated infertility (see Advanced Treatment
for Endometriosis-associated Infertility). Early in our experience in
treating infertility with Trental, many of our endo patients remarked that
their pain was unexpectedly improved. This experience has led us to
advocate Trental as a first line treatment for pelvic pain in endo.

Of interest in the treatment of pelvic pain, Trental has been found to
reduce the amount of endo tissue in animals with endometriosis.
Additionally, Trental has been recently used to treat chronic scarring in a
number of diseases. Extended treatment with Trental reduces fibrosis – a
key component of scarring or adhesions. It is possible that long term
administration of Trental will improve blood flow to pelvic organs and/or
help reduce pelvic scarring – two events that may improve the health of
these organs and reduce pelvic pain.

The standard dose of Trental is 400 mg given three to four times daily. At
the Sher Institute we have discovered that many drugs used to treat
gynecologic problems are more effective when administered as vaginal
suppositories. This is due to the fact that the blood supply from the
vagina goes directly to the uterus and pelvis before being returned to the
heart. Taking advantage of this unique circulatory pattern permits us to
target delivery of a high concentration of medication directly to the
pelvic organs. Vaginal administration of medications also reduces side
effects.

For the treatment of pelvic pain we administer Trental four times daily by
vaginal suppositories. Additional doses can be administered orally if
needed. Patients can expect relief from pain within four to six weeks.

Trental is a well tolerated medication. Fewer than 1% of patients report
noticeable side effects. Most common side effects include mild stomach
upset, dizziness, and headache.